碩士研究生課程:《質譜應用》、《有機質譜應用》
博士研究生課程:《有機質譜應用》
1. 二次電噴霧離子源關鍵技術及裝置研發
2. 基于質譜技術的呼氣代謝組及呼氣生物标志物研究
3. 面向無創檢測監測的轉化醫學及生物醫學工程研究
1. 國家自然科學基金委員會,優秀青年科學基金項目,環境分析化學,2022-01至2024-12,200萬元,在研;
2. 廣東省科學技術廳,廣東省基礎與應用基礎研究重大項目(基石)項目,重疾呼氣無創智能診斷技術的應用基礎研究,2024-01至2025-12,500萬元,在研;
3. 廣東省科學技術廳,廣東省國際科技合作項目,高性能二次電噴霧離子源的研制及其在環境與健康領域的應用,2022-01至2024-12,100萬元,在研;
4. 國家自然科學基金委員會,重大研究計劃培育項目,基于人體吸入和呼出氣中顆粒物粒徑譜和成分譜無損、實時分析的大氣細顆粒物暴露評價新方法研究,2016-01至2018-12,88.8萬元,已結題;
5. 國家科技部,重點專項課題,移動污染源VOCs排放快速在線監測技術研發,2016-07至2020-07,724萬元,已結題;
6. 廣東特支計劃,科技創新青年拔尖人才,人體呼氣代謝組直接質譜精準識别系統研發,2017-07至2020-06,30萬元,已結題。
(一)論文
1. Hui Huang, Jianming Yang, Chen Tao, Ligang Hu, Tao Huan, Wei Zhang, Keda Zhang*, Xue Li*. Exhaled breath analysis of non-volatile drugs, Towards clinical applications. TrAC Trends in Analytical Chemistry, 2024, 171, 177541.
2. Lei Li, Anthony S. Wexler, Xue Li*, Ligang Hu*, Guibin Jiang. In situ characterization of bioaerosols at the single-particle level using single-particle mass spectrometry, a promising tool for defending human health against bioaerosol transmission. Analytical Chemistry, 2023, 95(29), 10839–10843.
3. Huifan Deng†, Xin Xu†, Kangyi Wang, Jinli Xu, Gwendal Loisel, Yiqun Wang, Hongwei Pang, Pan Li, Zebin Mai, Shi-Chao Yan, Xue Li*, Sasho Gligorovski*. The effect of human occupancy on indoor air quality through real-time measurements of key pollutants. Environment Science & Technology, 2022, 56(22), 15377–15388.
4. Xing Chen†, Keda Zhang†, Zhihong Yin, Mingliang Fang, Weidan Pu, Zhening Liu, Lei Li, Pablo Sinues, Robert Dallmann, Zhen Zhou, Xue Li*. Online real-time monitoring of exhaled breath particles reveals unnoticed transport of non-volatile drugs from blood to breath. Analytical Chemistry, 2021, 93, 12, 5005–5008.
5. Huifan Deng, Jiangpin Liu, Yiqun Wang, Wei Song, Xinming Wang, Xue Li*, Davide Vione, Sasho Gligorovski*. Effect of inorganic salts on N-containing organic compounds formed by heterogeneous reaction of NO2 with oleic acid. Environmental Science & Technology, 2021, 55(12), 7831–7840.
6. Jiafa Zeng†, Majda Mekic†, Xin Xu, Gwendal Loisel, Zhen Zhou, Sasho Gligorovski*, Xue Li*. A novel insight into the ozone-skin lipids oxidation products observed by secondary electrospray ionization high resolution mass spectrometry. Environmental Science & Technology, 2020, 54(21), 13478–13487.
7. Jiafa Zeng†, Zhujun Yu†, Majda Mekic†, Jiangping Liu, Sheng Li, Gwendal Loisel, Wei Gao, Adrien Gandolfo, Zhen Zhou, Xinming Wang, Hartmut Herrmann, Sasho Gligorovski*, Xue Li*. Evolution of indoor cooking emissions captured by using secondary electrospray ionization high resolution mass spectrometry. Environmental Science & Technology Letters, 2020, 7(2), 76–81.
8. Xue Li*. Editorial of special issue on bridging aerosol chemistry and health impact. Science of the Total Environment, 2020, 713, 136699.
9. Sasho Gligorovski*, Xue Li*, Hartmut Herrmann. Indoor(photo) chemistry in China and resulting health impact. Environmental Science & Technology, 2018, 52(19), 10909–10910.
10. Xue Li*, Sasho Gligorovski*, Hartmut Herrmann. Underestimated contribution of HONO to indoor OH radicals: an emerging concern. Science Bulletin, 2018, 63(21), 1383-1384.
11. Xue Li†, Pablo Martínez-Lozano Sinues†, Robert Dallmann†, Lukas Bregy, Maija Hollmén, Steven Proulx, Steven A. Brown, Michael Detmar, Malcolm Kohler, Renato Zenobi*. Drug pharmacokinetics determined by real-time analysis of mouse breath. Angewandte Chemie International Edition, 2015, 54(27), 7815–7818.
12. Xue Li*, Renato Zenobi*. Use of polyetheretherketone as a material for solid phase extraction of hydroxylated metabolites of polycyclic aromatic hydrocarbons in human urine. Analytical Chemistry, 2013, 85, 3526–3531.
13. Xue Li†, Bin Hu†, Jianhua Ding, Huanwen Chen*. Rapid characterization of complex viscous samples at molecular levels by neutral desorption extractive electrospray ionization mass spectrometry. Nature Protocols, 2011, 6, 1010–1025.
(二)專利
1. 李雪,尹志紅,陳星,方明亮,帕布羅·辛紐斯. 一種生物氣體樣品中醛酮類物質的采集方法、分析方法及其裝置. 授權日期:2023.09.12. 專利号:ZL202110107936.4.
2. X.Li, Michael J. Xu. Method of collaboration between two multi-channel sampling devices. 授權日期:2022.10.25. 專利号(英國):GB2604083.
3. X.Li, Michael J. Xu, Z.Yin. Multi-channel gas sampling and detecting device with interval gas supply. 授權日期:2022.6.14. 專利号(英國):GB2587579.
4 X.Li, Michael J. Xu. Multi-channel sampling and detection device. 授權日期:2022.12.19. 專利号(英國):GB2604084.
5. 葉楓,張志娟,李征途,李雪,王彤,嚴秀英,周振,高偉. 馬爾尼菲籃狀菌病診斷的特征物及其篩選方法和應用. 授權日期:2020.09.10. 專利号:ZL 202010952586.7.
6. 李雪,斯林尼瓦蘇盧∙烏達甘德拉,黃磊,黃正旭,周振,帕布羅·馬丁内斯·洛薩諾辛紐斯,高偉,李磊. 一種亞微米氣溶膠化學組成的實時、在線快速質譜分析系統與方法. 授權日期:2018.05.15. 專利号:ZL201510150678.2.
7. 古穎綱,王伯光,李雪,周振. 垃圾填埋排放惡臭有機物的直接質譜分析方法. 授權日期:2017.02.22. 專利号:ZL2014-1-0421829.9.
8 方小偉,李雪,于志強,盛國英,傅家谟,陳煥文. 同位素稀釋電噴霧萃取電離串聯質譜快速檢測尿肌酐的分析方法. 授權日期:2014.07.09. 專利号:ZL201210191971.X.
9 李雪,陳煥文,李銀萍,方小偉,于志強,盛國英,傅家谟. 電噴霧萃取電離串聯質譜快速檢測尿中1-OHP的方法. 申請日期:2014.12.31. 專利号:ZL201210188912.7.
10. 黃俊,王泰,李雪,餘剛,鄧述波. 檢測船舶防污漆中滴滴涕組分的分析方法. 授權日期:2011.08.17. 專利号:ZL200810240262.X.
(三)獎勵
1. 2023年中華醫學會醫學科學技術獎二等獎,排名:6/6;
2. 2022年中國環境科學學會最美科技工作者獎;
3. 2021年廣東省環境科學學會生态環境青年科技優秀獎;
4. 2019年中國環境科學學會室内環境與健康分會何興舟室内環境與健康青年學術獎;
5. 2019年中國化學會青年環境化學獎;
6. 2016年中國環境科學學會優秀環境科技工作者獎;
7. 2015年中國儀器儀表學會科學技術獎一等獎,排名:7/10;
8. 2014年國家科技部創新人才推進計劃-重點領域創新團隊核心成員;
9. 2012年中國環境科學學會青年科技獎。
碩士研究生課程:《質譜應用》、《有機質譜應用》
博士研究生課程:《有機質譜應用》
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