研究生課程：《質譜應用》

1. 呼氣代謝組分析方法研究及其在臨床診斷、治療監測中的應用

2. 蛋白組學分析方法的研究及其在環境污染物毒理機制方面的應用

（一）論文

1. Xing Chen1, Xiaolan Hu¹, Xieguang Zhang¹, Hui Huang, Heng Meng, Jianming Yang, Chen Tao, Wei Zhang, Xue Li, Keda Zhang. Breath analysis: Harnessing its potential for non-volatile drug caffeine monitoring in human body. Microchemical Journal, 2024: 110130. (Co-first author)

2. Xiaolan Hu, Shilin Gong, Quan He, Jian-Lin Wu*, and Na Li^*. Less is more: A new perspective for toxicity of emerging contaminants by structures, protein adducts and proteomics. TrAC Trends in Analytical Chemistry, 2023, 117289.

3. Xiaolan Hu, Jian-Lin Wu^*, Wen Miao, Fei Long, Hudan Pan, Tao Peng, Xiaojun Yao, and Na Li^*. Covalent Protein Modification: An Unignorable Factor for Bisphenol A-induced Hepatotoxicity. Environmental Science & Technology,2022, 56, 9536−9545.

4. Shilin Gong¹, Xiaolan Hu¹, Shengshuang Chen, Baoqing Sun, Jian-Lin Wu*, Na Li*. Dual roles of drug or its metabolite-protein conjugate (DMPC): cutting-edge strategy of drug discovery using shotgun proteomics. Medicinal Research Reviews, 2022,42:1704-1734. (Co-first author)

5. Xiaolan Hu¹, Xiqing Bian¹, Wan-Yi Gu, Baoqing Sun, Xiang Gao, Jian-Lin Wu*, Na Li*. Stand out from matrix: Ultra-sensitive LC-MS/MS method for determination of histamine in complex biological samples using derivatization and solid phase extraction. Talanta, 2021, 225, 122056.

6. Xiaolan Hu, Xi-Qing Bian, Xin Wu, Jian-Yong Li, Hui-Ming Hua, Yue-Hu Pei, Ai-Hong Han, Jiao Bai*. Penioxalamine A, a novel prenylated spiro-oxindole alkaloid from Penicillium oxalicum TW01-1. Tetrahedron Letters, 2014, 55(29): 3864-3867.

7. Yue Zhuo, Yida Zhang, Meng Li, Haiying Wu, Shilin Gong, Xiaolan Hu, Yu Fu, Xinzi Shen, Baoqing Sun, Jian-Lin Wu, Na Li*. Drug Hepatotoxic Evaluation via Biomarker Quantification and Pathway Mapping of Large-Scale Chemical Proteomics. Food and Chemical Toxicology, 2021, 153, 112257.

8. Shilin Gong, Yue Zhuo, Shengshuang Chen, Xiaolan Hu, Xing-xing Fan, Jian-Lin Wu*, Na Li*. Quantification of Osimertinib and Metabolite-Protein Modification Reveals Its High Potency and Long Duration of Effects on Target Organs. Chemical research in toxicology, 2021, 34(11), 2309–2318.

9. Sajad Fakhri, Merve Tomas, Esra Capanoglu, Yaseen Hussain, Fatemeh Abbaszadeh, Baiyi Lu, Xiaolan Hu, Jian-Lin Wu, Liang Zou, Antonella Smeriglio, Jesus Simal-Gandara, Hui Cao, Jianbo Xiao*, Haroon Khan*. Antioxidant and anticancer potentials of edible flowers: where do we stand? Critical reviews in food science and nutrition, 2021,1–57.

10. Xiao-Cui Zhuang, Yong-Li Zhang, Gui-Lin Chen, Ye Liu, Xiaolan Hu, Na Li, Jian-Lin Wu, Ming-Quan Guo*. Identification of Anti-Inflammatory and Anti-Proliferative Neolignanamides from Warburgia ugandensis Employing Multi-Target Affinity Ultrafiltration and LC-MS. Pharmaceuticals (Basel, Switzerland), 2021, 14(4), 313.

11. Xiqing Bian, Jiao Bai*, Xiaolan Hu, Xin Wu, Chunmei Xue, Aihong Han, Guangyue Su, Huiming Hua, Yuehu Pei. Penioxalicin, a novel 3-nor-2, 3-seco-labdane type diterpene from the fungus Penicillium oxalicum TW01-1. Tetrahedron letters, 2015, 56(35): 5013-5016.

12. Xiao-Lei Zhou, Jiu-Hong WU*, Jiao Bai, Xiaolan Hu, En-Zhen LI, Ning SHI, Yue-Hu PEI. A new aristolactam alkaloid from the stems of Dasymaschalon trichophorum. Chinese Journal of Natural Medicines, 2013, 11(1): 81-83.

（二）專利

1. 裴月湖，白皎，陳剛，胡曉蘭。雙四氫苯并吡喃酮二聚體類化合物在抗癌藥物中的應用，發明專利，專利申請号： 201110332660.6

2. 李娜，伍建林，胡曉蘭。 一種篩選潛在共價藥物的方法, 澳門科技大學，發明專利，202310372589.7.

研究生課程：《質譜應用》

研究團隊專注于兩個前沿的科學領域：呼氣代謝組學和蛋白組學分析。在呼氣代謝組學方面，緻力于創新呼氣分析技術的開發與完善，旨在通過精準檢測呼出氣體中的生物标志物，為臨床診斷和治療藥物監測提供新的視角。在蛋白組學分析領域，專注于開發先進的蛋白組學方法，以深入探究環境污染物對人體健康的潛在影響，為環境保護和公共健康提供科學依據。

團隊配置有四極杆-靜電場軌道阱高分辨質譜、高分辨飛行時間質譜、氣相色譜質譜、離子阱質譜，并且配備有高效液相色譜儀、離子色譜儀和氣相色譜儀等色譜設備。這些儀器設備為實驗分析提供了可靠的研究平台。